Proper way to backup system, apps and settings

Since I just got stuck with a broken nightly on cyanogenmod I wanted to ask for a solid way to backup the system, apps and all settings of my device (which is a HTC one S ville).
I thought about backing up my cyanogenmod system with TWRP?
Is TWRP able to backup all the apps and app settings? Does it also include for exmple Tasker profiles?
What is a backup app like titanium for? Do I even need it if I back up frequently with TWRP?
Thanks in advance :)